BEIRUT: The death toll in United States airstrikes on pro-Iran installations in eastern Syria has risen to 19 fighters, a Syrian war monitor said today, in one of the deadliest exchanges between the US and Iran-aligned forces in years.

The US carried out strikes in eastern Syria in response to a drone attack on Thursday that left one American contractor dead, and another one wounded along with five US troops. Washington said the attack was of Iranian origin.

The retaliatory strikes by the US on what it said were facilities in Syria used by groups affiliated to Iran's Revolutionary Guard Corps left a total of 19 dead, according to the United Kingdom-based Syrian Observatory for Human Rights.

The war monitor said air raids killed three Syrian troops, 11 Syrian fighters in pro-government militias and five non-Syrian fighters who were aligned with the government.

The monitor's head Rami Abdel Rahman could not specify the nationalities of the foreigners. Reuters was unable to independently confirm the toll.

The initial exchange prompted a string of tit-for-tat strikes. Another US service member was wounded, according to officials, and local sources said suspected U.S. rocket fire hit more locations in eastern Syria.

President Joe Biden on Friday warned Iran that the US would "act forcefully" to protect Americans.

Iran has been a major backer of President Bashar al-Assad during Syria's 12-year conflict.

Iran's proxy militias, including Lebanese group Hizbollah and pro-Teheran Iraqi groups, hold sway in swathes of eastern, southern and northern Syria and in suburbs around the capital.

Teheran's growing entrenchment in Syria has drawn regular Israeli airstrikes but American aerial raids are rarer. The US has been raising the alarm about Iran's drone programme.

 -Reuters