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2019-10-11 18:07 | Report Abuse
It may take years to get through 5 phases clinical trials .
Phases of clinical trials
A clinical trial is only done when there is good reason to believe that a new test or treatment may improve the care of patients. Before clinical trials, tests and treatments are assessed in preclinical research. Preclinical research is not done with people. It assesses the features of a test or treatment. For example, the research may aim to learn if a device is harmful to living tissue. Another aim may be to learn more about the chemical makeup of a drug.
After preclinical research, tests and treatments go through a series of clinical trials. Clinical trials assess if tests or treatments are safe for and work in people. Clinical trials have five phases. The phases are described next using the example of a new drug treatment:
Phase 0
Phase 0 trials are the first clinical trials done among people. They aim to learn how a drug is processed in the body and how it affects the body. In these trials, a very small dose of a drug is given to about 10 to 15 people.
Phase I
Phase I trials aim to find the best dose of a new drug with the fewest side effects. The drug will be tested in a small group of 15 to 30 patients. Doctors start by giving very low doses of the drug to a few patients. Higher doses are given to other patients until side effects become too severe or the desired effect is seen. The drug may help patients, but Phase I trials are to test a drug’s safety. If a drug is found to be safe enough, it can be tested in a phase II clinical trial.
Phase II
Phase II trials further assess safety as well as if a drug works. The drug is often tested among patients with a specific type of cancer. Phase II trials are done in larger groups of patients compared to Phase I trials. Often, new combinations of drugs are tested. Patients are closely watched to see if the drug works. However, the new drug is rarely compared to the current (standard-of-care) drug that is used. If a drug is found to work, it can be tested in a phase III clinical trial.
Phase III
Phase III trials compare a new drug to the standard-of-care drug. These trials assess the side effects of each drug and which drug works better. Phase III trials enroll 100 or more patients.
Often, these trials are randomized. This means that patients are put into a treatment group, called trial arms, by chance. Randomization is needed to make sure that the people in all trial arms are alike. This lets scientists know that the results of the clinical trial are due to the treatment and not differences between the groups. A computer program is often used to randomly assign people to the trial arms.
There can be more than two treatment groups in phase III trials. The control group gets the standard-of-care treatment. The other groups get a new treatment. Neither you nor your doctor can choose your group. You will also not know which group you’re in until the trial is over.
Every patient in a phase III study is watched closely. The study will be stopped early if the side effects of the new drug are too severe or if one group has much better results. Phase III clinical trials are often needed before the FDA will approve the use of a new drug for the general public.
Phase IV
Phase IV trials test new drugs approved by the FDA. The drug is tested in several hundreds or thousands of patients. This allows for better research on short-lived and long-lasting side effects and safety. For instance, some rare side effects may only be found in large groups of people. Doctors can also learn more about how well the drug works and if it’s helpful when used with other treatments.
2019-10-11 10:47 | Report Abuse
Why Nova is allowed to sell hepar-p in the market since all clinical tests has not been passed?
shortinvestor77
Once Nova product hepar-p passes all clinical tests, the share price will boom a few folds.
10/10/2019 9:03 PM
2019-10-11 10:44 | Report Abuse
MBMR has been sleeping for 2 months. When will it wake up?
2019-10-10 21:21 | Report Abuse
The company is required to disclose any acquisition/disposal of interests in subsidiary or JV or Associate under QR note 11. Effect of Changes in the Composition of the Group.
"Investors must find out if CEO Andy Ang has sold his personal share in the joint venture to Jaks. Since he is controlling the company, he can make Jaks to buy his share without an EGM to seek the approval of shareholders."
2019-10-10 20:23 | Report Abuse
JAKS has 51% equity interest in JAKS Island Circle Sdn Bhd in property development business. No acquisition of Non Controlling Interests as stated in latest QR Cash Flow Statement. Therefore, Jaks has not acquired any remaining stakes from Andy.
"1, Jaks and its CEO Andy Ang are in JV to develop the Star Media land. It is one of the largest property developments in KL. It consists of 2 office tower blocks in front and 3 high rise condominium at the back. All these are sitting on a 4 storey underground car parks. Due to late construction completion, Star has forfeited the Rm 50 million performance bank guarantee and the High Court has passed judgement. Jaks is now trying to put an injunction to delay the payment of the Rm 50 million. The case has gone to Appeal Court.
Investors must find out if CEO Andy Ang has sold his personal share in the joint venture to Jaks. Since he is controlling the company, he can make Jaks to buy his share without an EGM to seek the approval of shareholders."
2019-10-10 19:54 | Report Abuse
Extracted from AR 2018 :
The current ongoing mixed development project at Section 13, Petaling Jaya known as Pacific Star achieved sales to-date of RM951 million (2017 : RM915 million), being 86% of the total gross domestic value (“GDV”) of approximately RM1.1 billion. The GDV and sales to-date included the Pacific Star Business Hub (“Business Hub”) which was sold to another subsidiary within the Group. The Pacific Star project is expected to complete by end- 2019 and the Group will take a step back from the property development sector for the time being in view of the current property market landscape. As at the end of March 2019, the Group has unbilled sales of RM203 million from its property development projects, giving the Group earnings visibility for the coming years.
The Business Hub at Pacific Star which is a four-storey retail and commercial centre, is expected to be completed in the second half of 2019 and will be operational before the year end. this commercial centre will serve the residents and offices from the surrounding established neighbourhood.
" Now Star and other buyers are demanding compensation for late completion under the Housing Ordinance. This will drag on for a long time until the project is completed. Even when Star Media project is completed, Jaks will have great difficulties to sell all the properties. "
2019-10-10 19:50 | Report Abuse
DK. Is it Uncle experience not up to date?
"Jaks also has a coal power plant contract to generate electricity to sell to the Vietnamese Government. Jaks has sold 70% of the contract to a Chinese Company for Rm 440 million which is to be paid during the power plant construction. Jaks is now reporting profit from this Rm 440 million which has attracted so many investors. From my experience in power plant construction, even after the power plant construction is completed, it will take more than 1 years to test run the huge muti- billion $ system. "
Posted by DK66 > Oct 10, 2019 5:53 PM | Report Abuse
https://baijiahao.baidu.com/s?id=1636755112157630248&wfr=spider&am...
越南永新燃煤电厂一期BOT项目2号机组自投产以来,一直维持高负荷连续运行,发电量共计28.27亿度,负荷率为98.17%,等效可利用系数99.78%,各项指标优良。2号机组高负荷连续运行
Vinh Tan 1 power plant continuous high load for 200 days since commercial operation. No time lag after CO
2019-10-10 19:39 | Report Abuse
You can refer to the interest expense 30 million in cash flow statement of AR 2018. Interest expenses capitalised in investment property in note 26. Finance Costs.
Posted by DK66 > Oct 10, 2019 7:30 PM | Report Abuse
Let me clarify, capitalized interest payments will not show up in the cash flow statement but added to the property development assets.
-----------------------------
Up_down An accountant can never hide interest payments as shown in the Cash Flow statement.
'Investors cannot see the amount of payment for interest charges for bank loan for the construction of the Star Media land because according to accounting rules, payment of interest can be capitalized.'
10/10/2019 7:23 PM
2019-10-10 19:23 | Report Abuse
An accountant can never hide interest payments as shown in the Cash Flow statement.
'Investors cannot see the amount of payment for interest charges for bank loan for the construction of the Star Media land because according to accounting rules, payment of interest can be capitalized.'
2019-10-10 19:19 | Report Abuse
My interpretation is not to drink too much XO as I did before. Who got so much XO to drink here? lolz
'My intention in writing this piece is to advise investors not to repeat the same mistake as I did before. I bought Jaks in anticipation of its future profit from its electricity power generation in Vietnam.'
2019-10-10 19:10 | Report Abuse
I am quite surprised that Uncle is so interested in knowing the details of the accounts. It doesn't seem like him as a businessman in the share market.
Goodwill RM 148 million was actually existed even before 2013.
According to its 2nd quarter accounts, it reported the following which investors must verify:
1, Rm 148 million for good will. Who has taken this money?
2, Rm 642 million in investment properties.
3, Rm 280 million in Joint Venture
4, Rm 318 million long term long.
5, Rm 82 million current bank loan.
6, Rm 935 million trade and other payable.
7, Rm 82 million cash at the beginning of the period and Rm30 million end of the period.
2019-10-10 18:29 | Report Abuse
How the share price can go up nicely if no strong operators get involved? This is the reality in share market and got nothing to hide.
2019-10-10 18:22 | Report Abuse
Thanks for your info. I am quite sure some China funds are standing behind controlling Jaks. Kyy got no choice and had to let go his stakes last time. I am expecting Jaks to trade max 90 cents today and breaking RM 1 by end of the month. I did not expect such number of crowd is attracted... It seems there are too many contra players get involved.
Posted by Ooi Teik Bee > Oct 10, 2019 6:09 PM | Report Abuse
Posted by Up_down > Oct 10, 2019 5:58 PM | Report Abuse
Jaks is too wild today. With such huge volume...No eye see next week.
I was told China firm was interested to buy a block of Jaks shares a year ago, my VIP client expected the share price of Jaks will skyrocket up into the sky. However, it did not happen at the time.
The present up surge may imply someone is interested to buy a block of Jaks shares. I do not know, I just speculate only. The volume is very high now to make me to recall the event.
This information is what I heard a year ago.
Thank you.
Ooi
2019-10-10 17:58 | Report Abuse
Jaks is too wild today. With such huge volume...No eye see next week.
2019-10-10 15:39 | Report Abuse
Share price remains trending upward. Go Go Go!
2019-10-10 15:37 | Report Abuse
Volume close to 80 million in a day. @-@
2019-10-10 09:59 | Report Abuse
They are fast and furious. Tak Boleh cari makan if it marchs so slow. See what would happen by this month la.
2019-10-10 09:54 | Report Abuse
TP RM 1 by year end? You must be kidding. Look down on OTB summons.
2019-10-09 15:02 | Report Abuse
Making money is just like a piece of cake to you. You are well respected in the market cause you are able to resist your single VVVIP client pressures and protecting interests of other smaller clients.
Posted by Ooi Teik Bee > Oct 9, 2019 2:21 PM | Report Abuse
Posted by Up_down > Oct 9, 2019 12:04 PM | Report Abuse
There's a lot different between the price RM 1.4 promoted by Uncle comparing with nowadays. His advisor didn't dare to take so much risks in his reputation and rice bowl. It's simply mismatching of risks and rewards.
Ans :
You are very good. It is risk against reward.
I do not assume, I want facts and figures to get convinced.
I treasure more on my reputation than rice bowl.
I bought 500k of Jaks at 0.50 before Mr Koon bought it.
I sold at 1.00 for 100% gain.
Now the price is less than 1.00.
The risk now is very low.
Moreover, the price is very low now compared against 1.40.
Thank you.
Ooi
2019-10-09 12:04 | Report Abuse
There's a lot different between the price RM 1.4 promoted by Uncle comparing with nowadays. His advisor didn't dare to take so much risks in his reputation and rice bowl. It's simply mismatching of risks and rewards.
2019-10-09 11:40 | Report Abuse
Hard to say. This is the biggest black mark in his investment history. It could be an opportunity for him to take revenge on Jaks to recover part of his reputation. The scale would certainly smaller than previous attack.
2019-10-08 19:31 | Report Abuse
This could be the best timing to invest in Jaks since the price is much lower comparing with last year. Progress of power plant is ahead of schedule. High demand of electricity in Northern Vietnam since the trade war erupted. It is a High gain and Low risks given limited options available for investing high growth shares in KLSE. No time to wait until everything is settled down.
2019-10-08 14:51 | Report Abuse
Funds Managers are also exhausted in looking for high growth companies in KLSE. It's simply very limited available nowadays. They would join the boat soon.
2019-10-07 19:28 | Report Abuse
This type of same positive and negative information can be recycled for more than 10 times for Jaks in a year. Old birds would certainly ignore it...so who else would take such recycling stories seriously?
2019-10-07 17:18 | Report Abuse
There’s no right or wrong. It’s just people have their own way of cari makan in stock market.
2019-10-07 17:13 | Report Abuse
Short term traders like that la...after I buy, I would post positive information until I sell. After I sell, I would dish out negative information until I buy again. The cycle repeat and recycling of information.
2019-10-07 16:26 | Report Abuse
Redtone is supported by OTB. Huat liao. I thought he only focus in low PER growth companies.
2019-10-07 11:45 | Report Abuse
We will hear the same voice again again after the the share price break RM 1.
2019-10-07 11:23 | Report Abuse
Add more since Jaks will report construction profits at least in next 4 quarters. It may follow the path of MFCB whereby share price trending upward while reporting more construction profit.
2019-10-07 09:38 | Report Abuse
Price is still trending upward regardless of small number of voices. Waiting patiently.
2019-10-07 09:30 | Report Abuse
With such future prospects, Redstone would attract more dream chasers. Sky is the limit.
2019-10-03 19:46 | Report Abuse
No easy life in stock market especially KLSE. The up and down cycle in a short period is really shaking our heads.
2019-10-03 19:39 | Report Abuse
The tricky part is how to maintain our confident while keep cutting lost.. It is, in fact, life torturing during the process and may have to endure it for years.
2019-10-03 19:29 | Report Abuse
Practice of cutting loss until you don't have much feeling in loosing money.
Posted by Moore > Oct 3, 2019 7:03 PM | Report Abuse
Guys can share some proven trading strategies I can learn?
2019-10-03 19:25 | Report Abuse
But I hardly see kyy come back to goreng the same counter twice. lolz
2019-10-03 19:17 | Report Abuse
Nothing is certain in the market for short and mid term. Don't be too confident in your word.
Posted by stockraider > Oct 3, 2019 7:10 PM | Report Abuse
Yes don have to act smart but better don be another sohai loh...!!
2019-10-03 19:08 | Report Abuse
Sometimes, we don't have to act smart in stock market. Stock market is an irrational place for people playing game...follow the trend will do. lolz
Posted by stockraider > Oct 3, 2019 7:02 PM | Report Abuse
just don be another sohai loh...!!
2019-10-03 19:01 | Report Abuse
kyy lost 60 million in Jaks. Pengoreng have earned so much money in such a short time. They will come back one.
Posted by stockraider > Oct 3, 2019 6:50 PM | Report Abuse
No counting chicken b4 it hatch loh...!!
The power plant not producing any power n still under development loh...!!
Better to buy insas.....its chicken already hatch & inari already moving up loh....!!
Too much risk & uncertainty for jaks power plant mah...!!
2019-10-03 18:56 | Report Abuse
There is no such 'shameful' or 'shame' words in politicians' dictionary. It's only INTEREST in their mind. He has to learn more from Dr M on how to thicken his face skin.
2019-10-03 16:58 | Report Abuse
FF is running out of KLSE like no tomorrow. They can invest elsewhere in more competitive market such as SGX banking shares. Not much hope for this blue chip. Headwinds cycle is now staging in KLSE finance counters.
2019-10-03 15:59 | Report Abuse
RainT. No exciting now but it's OK since the prices have been staying ut quite low in comparing with peers. Expecting YSPSAH to deliver better QR in next few quarters after taking into account contributions from expansion.
2019-10-03 15:27 | Report Abuse
Diam diam beli sampai hot hot baru jual.
2019-10-03 15:19 | Report Abuse
Business expansion is supported by new aerospace segment from the orders given by UACE. Good future prospects.
2019-10-03 10:13 | Report Abuse
Goods news for new project. Go go go!
2019-10-03 10:10 | Report Abuse
Vietnamese government is restricted borrowing in USD to reduce dollarization recently. Not sure if there is any effect to Hai Duong plant loans.
Vietnam central bank clamps down on foreign currency borrowing for imports
https://e.vnexpress.net/news/business/economy/vietnam-central-bank-clamps-down-on-foreign-currency-borrowing-for-imports-3989739.html
The US$1.4b borrowing is in US$ and is financed by 3 chinese banks.
Posted by DK66 > Oct 3, 2019 9:43 AM | Report Abuse
The US$1.4b borrowing is in US$ and is financed by 3 chinese banks.
2019-10-03 09:41 | Report Abuse
DK66. Finance cost is rather high in Vietnam. Average interest rate 9% is more suitable in reflecting current prevailing market rate.
2019-09-30 14:17 | Report Abuse
No catalyst yet but it's still a good bargain at this price level.
2019-09-30 14:15 | Report Abuse
Add more and patiently wait for the next QR announcement.
2019-09-30 14:09 | Report Abuse
Momentum is backed after flushing out weak holders. Go go go!
Stock: [NOVA]: NOVA WELLNESS GROUP BERHAD
2019-10-11 18:21 | Report Abuse
If Hepar-P is able to complete 3rd clinical trials, MNC may come to take over Nova. lolz
Posted by shortinvestor77 > Oct 11, 2019 5:32 PM | Report Abuse
Clinical trial of Hepar-P Capsule ( is for the treatment of non-alcoholic fatty liver disease.
2015
Completed the first clinical trial of Hepar-P Capsule for the treatment of non-alcoholic fatty liver disease.
2017
Ready for the second clinical trial of Hepar-P Capsule for the treatment of non-alcoholic fatty liver disease.
http://nova.my/history