Lecanemab causes brain to shrink even faster! -------------------------
Lecanemab and other drugs that remove amyloid have another side effect that is more mysterious: They seem to cause the brain to shrink.
That concerns scientists including Thambisetty.
"Brain shrinkage represents disease progression," he says. "What is a little worrying to me is that these drugs might be worsening the degenerative process."
Alzheimer's itself causes the brain to shrink, a sign that neurons are dying. So Thambisetty expected Alzheimer's drugs to limit shrinkage, rather than accelerate it.
So did Dr. David Knopman of the Mayo Clinic. "It's moving in the wrong direction," he said during a panel at the Alzheimer's meeting.
Thambisetty wants Eisai to publish detailed information about the changes in brain volume that occurred during its study of lecanemab.
@DestinyL, rate of brain atrophy is one of the endpoint measurement in lucidity trial. This is the purest form of biomarker in a clinical trial compared to reduction of amyloid deposits. Patients taking HMTM can see slower rate of brain atrophy.
I think some amyloid drugs are so harsh at clearing away amyloid plaques that somehow it even manage to clear away a little tau tangles. Hence can see some cognition slowdown but this is largely due to a small reduction in tau tangles. Eli lily keep touting their donanemab clears amyloid deposits faster n can even clear away some Tau tangles.
Thambisetty is a current FDA Adcom panel member while David Knopman resigned as FDA Adcom panel member in protest due to FDA's Aduhelm accelerated approval fiasco.
Demographics of M needs 1 casino only. 2 casinos overlap compete another same c License is extremely difficult to obtain. Rules & regulations are very restrictive. Costs very high to set up casino resort. ROI may take too long. Opportunity costs are too high. Set up abroad offers more ROI potential Earn higher returns, rev, profit, foreign exch
Better opportunities abroad. Set up casinos in US, Thai, EU, China.
Its ok geh if 2nd casino in Penang operated by Genting Rich penangites as well as Thai tourists can all flock to Penang while Highlands cater more towards leisure+casino mixed
DestinyL, cannot lah. Thai planning open up to 5 casinos alrdy ! If half approved, got 2 - 3 new casinos alrdy 2 - 3 new casinos, M visit T instead, lol Pnites/M'sians go T for leisure+ casino !
China currently bracing for the first wave of Omicron. Lots of infection in many areas/cities, but most numbers are not officially reported. May take at least 3 months for the wave to subside. Currently Chinese are not allowed to travel freely, except for specific purposes (e.g. business, education, visiting relatives). Have to wait for policy to loosen up, maybe next year?
PETALING JAYA: Genting Malaysia Bhd (GenM) has a few positive things going on that will make financial year 2023 (FY23) exciting for the gaming and resort operator.
They include the reopening of the remaining hotel room inventory in Resorts World Genting (RWG) in Genting Highlands, SkyWorld ride capacity increase and extended operating hours as well as a seasonally stronger Chinese New Year period.
In addition, there will also be favourable developments in the United States, with the opening of Resorts World Hudson Valley (RWHV) this month and Super Bowl in February 2023, which augured well for its subsidiary Empire Resorts Inc’s mobile sports betting.
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AngTayKor
1,604 posts
Posted by AngTayKor > 2022-12-10 13:17 | Report Abuse
Lecanemab causes brain to shrink even faster!
-------------------------
Lecanemab and other drugs that remove amyloid have another side effect that is more mysterious: They seem to cause the brain to shrink.
That concerns scientists including Thambisetty.
"Brain shrinkage represents disease progression," he says. "What is a little worrying to me is that these drugs might be worsening the degenerative process."
Alzheimer's itself causes the brain to shrink, a sign that neurons are dying. So Thambisetty expected Alzheimer's drugs to limit shrinkage, rather than accelerate it.
So did Dr. David Knopman of the Mayo Clinic. "It's moving in the wrong direction," he said during a panel at the Alzheimer's meeting.
Thambisetty wants Eisai to publish detailed information about the changes in brain volume that occurred during its study of lecanemab.