No. Not effectively. Flash memory have a finite number of reads and writes. More reads than writes. Once that number is exceeded it will stop working. Hard drives have hundreds of thousands of times more write cycles. A typical day your hard drive may be written to over 100,000 times. More if doing an update. A flash memory will stall permanently if it were to perform an update.

SSDs also have a limited number of writes but more than a flash drive. To be gentle on the SSDs, the operating system should be running “Trim” which reduces significantly the number of writes to it. Modern OSs have “trim” preinstalled and running. Older OSs you have to download and manage it.