Posted by Riaz1954 > 2022-06-02 22:33 | Report Abuse

At current price level, the risk / reward favours investment even without the drug outcome being favourable. Genting price will recover well past 6 mark when it’s core activities and markets pick up. If you then add the remote probability of the the drug being successful then any thing is possible. So the risk is worth taking for a significant uplift in price if the drug receives approval and is successful. To me reading the trial,results suggest that it is not totally unrealistic for the outcome to be positive.

Posted by ETTUSA > 2022-06-02 22:34 | Report Abuse

Aberdeen Alzheimer’s drug on fast track for approval after trial found it slows progress of dread disease

https://www.pressandjournal.co.uk/fp/business/local/4361694/aberdeen-alzheimers-drugs-slows-progress-of-dread-disease/

Posted by ETTUSA > 2022-06-02 22:35 | Report Abuse

Aberdeen Alzheimer’s drug on fast track for approval after trial found it slows progress of dread disease

https://www.pressandjournal.co.uk/fp/business/local/4361694/aberdeen-alzheimers-drugs-slows-progress-of-dread-disease/

Posted by choysun > 2022-06-02 22:37 | Report Abuse

RM4.2m IDSS today. Wonder if they made money. Hmm

Posted by emsvsi > 2022-06-02 22:43 | Report Abuse

On the fast track

Prior to the release of the interim data, the drug was awarded an “innovation passport” by the UK’s drug development regulator in order to speed it through becoming more widely available to people affected by the disease.

Medicines

Posted by emsvsi > 2022-06-02 22:44 | Report Abuse

YES ON THE FAST TRACK BABEHHH LIKE THE GROUND BREAKING MRNA VACCINES

Posted by emsvsi > 2022-06-02 22:45 | Report Abuse

GENTING TO THE NEXT GALAXY !

Posted by DestinyL > 2022-06-02 22:47 | Report Abuse

Just sleep on it

Posted by ETTUSA > 2022-06-02 22:49 | Report Abuse

4 to 6 week only fast track innovative passport.. Hold tight...

Posted by emsvsi > 2022-06-02 22:52 | Report Abuse

YES ETTUSA MODERNA WENT FROM $15 to $500 BUT THERE IS ONE DIFFERENCE ! ALZHEIMERS IS NOT A ONE OFF LIKE THE PANDEMIC !

Posted by emsvsi > 2022-06-02 22:52 | Report Abuse

GENTING IS FOREVER AND ETERNAL IN UNCLE LIM WE TRUST

Posted by emsvsi > 2022-06-02 22:58 | Report Abuse

TOMORROW WE TEACH THE SHORTS THAT THEY MAY TAKE OUR LIVES, BUT THEYLL NEVER TAKE OUR SHARESSSSS

Posted by choysun > 2022-06-02 23:04 | Report Abuse

@emsvsi Braveheart speech ah? :p

Posted by emsvsi > 2022-06-02 23:14 | Report Abuse

YES CHOYSUN "Fight and you may die. Run, and you’ll live… at least a while. And dying in your beds, many years from now, would you be willin’ to trade all the days, from this day to that, for one chance, just one chance, to come back here and tell our enemies that they may take our lives, but they’ll never take… our freedom!"

Posted by cktay > 2022-06-03 00:21 | Report Abuse

Foreign funds have been snapping up Genting like crazy after news broke out while many retailers were still in the blank!
Last week foreign funds net buy …… Mon -36m, Tues -163m, Wed +2m, Thu +43m, Fri +71m
This week ….. Monday +122m, Tues +321m, Wed +111m

Posted by cktay > 2022-06-03 00:21 | Report Abuse

The Phase 2 trial …. 321 patients with an earlier version of the drug showed a 90% reduction in the rate of disease progression over two years.
The result was supported by functional brain imaging.
(Imaging identified the regions within the brain known to be affected by Alzheimer’s neuropathology that were protected by the drug)
…. “reduce clinical decline and brain atrophy by about half over 12 months”
Phase 2 results were already highly significant!

Posted by cktay > 2022-06-03 00:21 | Report Abuse

Now Phase 3 just completed…. 12 month blinded study [A double-blind clinical trial is one in which both the recipient and the administrator does not know if the recipient is receiving the actual drug] …. tested in 598 people with Alzheimer’s……
“participants receiving HMTM decline at a rate substantially less than is typical in Alzheimer’s” (using very modest wordings)
They will tell more on June 9, 2022 at the 35th Global Conference of Alzheimer's Disease International.

Posted by cktay > 2022-06-03 00:22 | Report Abuse

What comes after a Phase 3 clinical trial?
After the Phase III trial, the FDA reviews the clinical trial results to make sure the treatment is safe and effective for people to use. The FDA decides whether to approve the treatment so that it is available for all patients.

Posted by cktay > 2022-06-03 00:22 | Report Abuse

• How long does it take for the FDA to get it approved so that it is available to all patients?
It may be within months like in the Covid-19 m-RNA vaccine or it may take years.
But I reckon it may be sooner rather than later, because there is up to now no other cure for 50million patients, their condition deteriorating by the day.
many unable to move around on their own, unable to speak or make oneself understood, difficulty eating and swallowing. On the average, a person with Alzheimer's dies within four to eight years after diagnosis.
Alzheimer's is one of the most expensive diseases in the US, costing an estimated $305 billion — including $206 billion in direct costs to Medicare and Medicaid — in 2020.
The effect on family member diagnosed with Alzheimer's disease can be overwhelming.
The UK regulatory authority already granted TauRx an Innovation Passport. This is the first stage which is intended to accelerate development and approval times, facilitating access to new products and indications.

Posted by cktay > 2022-06-03 00:22 | Report Abuse

Hydromethylthionine mesylate (HMTM) is taken orally as a tablet hence ease of distribution, storage, prescription and administration.
It is actually a form of Methylene Blue, an old drug that was used for treatment for malaria, methemoglobinemia and other conditions. I reckon it should not be too expensive to manufacture. Its safety profile is also favourable and consistent with previous studies.

But because of heavy investments in time and money in which 90% of drug candidates in clinical trials fail, new block buster drugs do not come cheap. Brand-name approved prescription drugs are sold at extremely high prices in the US because patents allow drugmakers to call the shots when it comes to how much American patients pay for their prescriptions.
It becomes either you take it or you progress until you cannot recognize your husband, wife or children, till finally you die!
Genting invested USD112m since 10 years ago just like a calculated gamble, surely Genting wants returns of its investment many folds!

Posted by Income > 2022-06-03 00:23 | Report Abuse

Prof Emsvsi, thanks for your very courageous words.
Prof. Emsvsi, as a gentle reminder, the night is very late now, please go to slumber. Or else you will get Lots of Tau Entanglements… might progress to Alzheimer???
I need to rush to sleep now. See you again tomorrow, Prof Emsvsi.

Posted by Peaches L > 2022-06-03 00:34 | Report Abuse

@cktay, thks very much and greatly appreciate yr lengthy and in-depth sharing.

Posted by Peaches L > 2022-06-03 00:40 | Report Abuse

@Income, u addressed d msg to wrong person. U really must retire ASAP b4 Alzheimer’s sets upon u. Hahaha… gd nite and rest well.

Posted by AngTayKor > 2022-06-03 00:42 | Report Abuse

Posted by cktay > 6 minutes ago | Report Abuse

The Phase 2 trial …. 321 patients with an earlier version of the drug showed a 90% reduction in the rate of disease progression over two years.
The result was supported by functional brain imaging.
(Imaging identified the regions within the brain known to be affected by Alzheimer’s neuropathology that were protected by the drug)
…. “reduce clinical decline and brain atrophy by about half over 12 months”
Phase 2 results were already highly significant!
-------------------------------------------------------

Thats the "REMBER" phase 2 trial completed somewhere in 2008 under the first generation drug formula MTC. But MTC formula is highly inefficient and did not work well at high dose. The 2nd generation formula HMTM is very efficient, 60 times the absorption rate into our blood brain barrier compared to the same dosage under MTC formula. Too efficient until the placebo 4mg twice daily was actually an active dose. Both arms of trial patient groups receiving active doses. Hence Taurx failed their Phase 3 trials back in 2016 due to dosage issues. Cost us USD200m plus a 6 years delay in re-trial.

Posted by newbie2019 > 2022-06-03 07:32 | Report Abuse

as long as FF keeps buying, the price is highly going high high hehehehe

good morning guys!!!

Posted by Income > 2022-06-03 07:39 | Report Abuse

Good morning.
Semboi.
Have you say your prayers for Good Health and for Genting?

Posted by Income > 2022-06-03 07:42 | Report Abuse

FF buying and FF shareholdings are not permanent lah. Don’t count on FF lah.
When the honey is dried, FF will run road faster than Road Runner.
That’s FF coming is for one night stend only.

Posted by Income > 2022-06-03 07:45 | Report Abuse

Income coming for G is much better than FF coming.

Posted by Riaz1954 > 2022-06-03 08:21 | Report Abuse

No brainer ……strong case to invest in Genting ….but long weekend will bring selling pressure as small holders sell for spending money! Any correction is an opportunity to add.

Posted by Income > 2022-06-03 08:23 | Report Abuse

Having Roti Tissues for breakfast this morning. Clear the throat with Teh Tarik. Sedapnya.

Posted by Income > 2022-06-03 08:25 | Report Abuse

Don’t fall in love with anything in this world. Nothing is permanent.

Posted by emsvsi > 2022-06-03 08:29 | Report Abuse

YES DIAMONDS ARE FOREVER BUT INCOME IS NOT

Posted by Income > 2022-06-03 08:33 | Report Abuse

Any stocks without Income is Useless lah.

Posted by Income > 2022-06-03 08:36 | Report Abuse

Diamonds can be made from graphites. Diamonds is overrated. Gold is really precious than Diamonds. Gold can’t be made by man. Haha

Posted by Income > 2022-06-03 08:43 | Report Abuse

Enjoy the wild ride.

Posted by LossAversion > 2022-06-03 08:44 | Report Abuse

How come Genting Bhd's AGM (Today) is NOT listed in i3investor Meeting calendar????

Posted by emsvsi > 2022-06-03 09:00 | Report Abuse

GET READY TO RUMBLEEEEE

Posted by virust > 2022-06-03 09:20 | Report Abuse

Why HMTM need approval from FDA. This drug is made from UK and UK leave EU already so not EMA as well and must be approval from MHRA first.

Posted by virust > 2022-06-03 09:25 | Report Abuse

Last Corona vaccine dated at 2002 during SARS and failed for period of 20yrs but new mRNA vaccine for covid only took a year from the ground to approval.

Posted by Income > 2022-06-03 09:37 | Report Abuse

VirusT, give respect to Big Bro Uncle Sam lah. So need approval from FDA first. You don’t know kah?

Posted by WinSSP > 2022-06-03 09:41 | Report Abuse

Thanks greatly for clear n succinct knowledge sharing from @cktay & @virust.
That fake fella only cut & paste with broken grammar lol

Posted by DestinyL > 2022-06-03 09:43 | Report Abuse

If want to sell in US, must get FDA approval right? Just looking at it on common sense

Posted by Income > 2022-06-03 09:45 | Report Abuse

VirusT, that’s to show Big Bro Uncle Sam power in this world. You don’t know Uncle Sam is the only unipolar superpower kah?

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Posted by virust > Jun 3, 2022 9:25 AM | Report Abuse

Last Corona vaccine dated at 2002 during SARS and failed for period of 20yrs but new mRNA vaccine for covid only took a year from the ground to approval.

Posted by Income > 2022-06-03 09:51 | Report Abuse

VirusT… That’s why Big Bro Uncle Sam candy wrappers dolars are still in demand because of its military might. If Uncle Sam military is weak, do you think countries like China obeys US and keep US dolars?

Posted by WinSSP > 2022-06-03 09:55 | Report Abuse

auntie Income, that’s exactly what @virust meant in his posting la. All serious GB investors alredy knew FDA’s approval is a must…no need uncle sam here, uncle sam there

Posted by WinSSP > 2022-06-03 09:56 | Report Abuse

Agree @Riaz. Hope everyone can plan for some nice travels or buy new car, new house since can take profit or make huge paper profit from GB :)
Ah pek & auntie no need post till midnight everyday… Find some friends la

Posted by emsvsi > 2022-06-03 10:28 | Report Abuse

HODL THE LINE GENTING SHAREHOLDERS !

Posted by virust > 2022-06-03 10:32 | Report Abuse

Why need to sell to US only 329mil ppl. Just sell to Indonesia can cover 270mil ppl already and some more it is halal for MY as well. Those who lost memory and short memory can buy HMTM at Waston in near future.

Posted by Income > 2022-06-03 10:32 | Report Abuse

Hello Aunty, why you want to suggest activities for us here? This is a free forum. I also don’t care what you say here.
We are free to chat until midnight lah. Are you a traffic warden here? Haha. I talk to VirusT, you also want to interfere kah? Take care of yourself lah.

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Posted by WinSSP > Jun 3, 2022 9:56 AM | Report Abuse

Agree @Riaz. Hope everyone can plan for some nice travels or buy new car, new house since can take profit or make huge paper profit from GB :)
Ah pek & auntie no need post till midnight everyday… Find some friends la


Posted by WinSSP > Jun 3, 2022 9:55 AM | Report Abuse

auntie Income, that’s exactly what @virust meant in his posting la. All serious GB investors alredy knew FDA’s approval is a must…no need uncle sam here, uncle sam there

Posted by emsvsi > 2022-06-03 10:34 | Report Abuse

LOW VOLUME IT IS ONLY PROFIT TAKING OVER THE WEEKEND HAVE FAITH !